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PSB 1115

CAS No. 152529-79-8

PSB 1115( —— )

Catalog No. M27689 CAS No. 152529-79-8

PSB 1115 is an A2B receptor antagonist and can counteract the inhibitory effect of NECA.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    PSB 1115
  • Note
    Research use only, not for human use.
  • Brief Description
    PSB 1115 is an A2B receptor antagonist and can counteract the inhibitory effect of NECA.
  • Description
    PSB 1115 is an A2B receptor antagonist and can counteract the inhibitory effect of NECA.(In Vitro):PSB 1115 reversed the decrease in plasma insulin induced by NECA.(In Vivo):The effect of PSB 1115 was obvious in diabetic GotoKakizaki rats: plasma insulin was increased whereas blood glucose was unchanged. The adenosine levels were not different in normal Wistar rats and in diabetic GotoKakzaki rats.
  • In Vitro
    ——
  • In Vivo
    PSB-1115 (0.5 mg/kg; i.p.; single dose, 20 min before the inhalation) antagonizes the inhibitory effect of non-selective adenosine receptor agonist NECA (HY-103173) on mucociliary clearance in mice.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    PEGs|Alkyl/ether
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    152529-79-8
  • Formula Weight
    350.35
  • Molecular Formula
    C14H14N4O5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCCn1c(=O)[nH]c2nc([nH]c2c1=O)-c1ccc(cc1)S(O)(=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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